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AC Compressor blows up
The compressor disintegrates and spreads fine metal throughout the AC system. Everything has to be replaced as the debris will not flush out. Full kits are now available including all the bits, and at something of a discount from the individual pieces. The dealer prices are much higher and put the cost of repair near the value of the depreciated value of the vehicle.
While the book allots 13 hours for the repair, the Sienna layout is almost like they built an air conditioner and put the van around it. Both the engine compartment and dashboard, as well as the rear quarter where the rear condenser sits, have to come apart. Unless your mechanic has done it before, they may not know about the kit, or the time to execute the repair.
If you are looking at a used Sienna, look for this having happened already or expect it as part of ownership into the second hundred thousand.