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Comments
The only realistic solution in my opinion is, if possible, isolate the animal to the back cargo area (in an SUV type vehicle) and use a protective covering from a company such as Weathertech, (http://www.weathertech.com/) which specializing in doggie protection products. If the dog sits in the back seat, you'll have to cover it with something.
For cloth seats you can also apply a Scotchguard product to help with cleanup.